منابع مشابه
Telomeres and immunological diseases of aging.
A defining feature of the eukaryotic genome is the presence of linear chromosomes. This arrangement, however, poses several challenges with regard to chromosomal replication and maintenance. To prevent the loss of coding sequences and to suppress gross chromosomal rearrangements, linear chromosomes are capped by repetitive nucleoprotein structures, called telomeres. Each cell division results i...
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Clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. This attitude is no longer acceptable. Surge of information and discoveries in neurosciences within the last two decades translated into therapeutic interventions which is literally life saving in some o...
متن کاملTelomeres and aging.
Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must "cap" each chromosome end to avoid activation of DNA repair pathways. Repair of critically short or "uncapped" telomeres by telomerase or recombination is limit...
متن کاملAging, telomeres, and atherosclerosis.
Although the level and pace of population aging display high geographical variability, virtually all countries have been experiencing growth in their elderly population, particularly in developed nations. Because aging is a major risk factor for atherosclerosis and associated disease, it is of up most importance to unravel the molecular mechanisms involved in vascular aging. Telomeres are speci...
متن کاملTelomeres and Reproductive Aging
Telomeres are special deoxyribonucleic acid (DNA) structures that “cap” the ends of eukaryote chromosomes. The term telomere derives from the Greek words telos, meaning “end”, and meros meaning “part”. The existence of these end-parts of chromosomes was first suggested in 1938 by Muller (Muller, 1938). Telomere length is involved in biological aging and disease processes. Telomere length is aff...
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ژورنال
عنوان ژورنال: Gerontology
سال: 2010
ISSN: 1423-0003,0304-324X
DOI: 10.1159/000268620